Interaction between Vitamin D-Related Genetic Risk Score and Carbohydrate Intake on Body Fat Composition: A Study in Southeast Asian Minangkabau Women

Metabolic diseases have been shown to be associated with low vitamin D status; however, the findings inconsistent. Hence, objective of our study was investigate relationship between status and metabolic disease-related traits in healthy Southeast Asian women examine whether this modified by dietary factors using a nutrigenetic study. The included 110 Minangkabau (age: 25–60 years) from Padang, Indonesia. Genetic risk scores (GRS) were constructed based on five D-related single nucleotide polymorphisms (SNPs) (vitamin D-GRS) ten disease-associated SNPs (metabolic-GRS). metabolic-GRS significantly lower 25-hydroxyvitamin (25(OH)D) concentrations (p = 0.009) higher body mass index (BMI) 0.016). Even though D-GRS had no effect > 0.12), an interaction observed carbohydrate intake (g) fat percentage (BFP) (pinteraction 0.049), where those individuals who consumed high diet (mean ± SD: 319 g/d 46) carried >2 D-lowering alleles BFP In summary, we replicated association BMI 25(OH)D identified novel composition.